GEORGIOS DRYLLIS
Laiko University Hospital, Athens, Greece
Title: T786C polymorphism of eNOS gene and risk of developing atherosclerosis in women with endopelvic endometriosis
Biography
Resident physician in the specialty of Hematology in Laiko General University Hospital of Athens Athens: 2013- nowadays: Ph. D Candidate of the Medical School of Athens on the thesis: Gene polymorphisms and pregnancy outcome Alexandroupolis: 2005- 2010: Bachelor studies in Medical School of Democritus University of Thrace and graduation in 2010 with grade: very well- 7,07/10. Patras: 2005-2007: Studies in the post-graduate program â?~Applications in Basic Medical Sciencesâ?T, Medical School in University of Patras. M. Sc graduation in 2007 with grade: excellent â?" 10/10. M. Sc Thesis: Construction of episomal vector for the activation of the artificial transcription factor of g-globin gene in human hematopoietic stem cells. Molecular genetics and Cytogenetics sector, Supervisor Mrs. Aglaia Athanassiadou 2005-2007: I gained scholarship from the â?~State Scholarships Foundationâ?T. Alexandroupolis: 2000-2004: Bachelor studies in Molecular Biology and Genetics School of Democritus University of Thrace and graduation in 2004 with grade: very well- 8,21/10. Thesis: Clinical and molecular study of major beta-thalassemia mutations in Greece. I worked for seven months in the laboratory of prenatal diagnosis in hemoglobinopathies in Laiko Hospital, with Mrs. Loutradi-Anagnostou as Supervisor Membership of Professional Bodies and Learned Societies: Member of: â?¢ Scientific Company of Medical School Students of Greece â?¢ Greek Molecular Biology Society â?¢ Greek Haematology Society Career details to-date: PROFESSIONAL CLINICAL EXPERIENCE September 2014- nowadays: Resident physician in the specialty of Hematology in the Internal Medicine Clinic of Pathology-Physiology in Laiko General University Hospital of Athens March 2014- September 2014: Resident physician in the specialty of Hematology in Tzaneio Hospital of Piraeus July 2012- March 2014: Resident physician in the specialty of Internal Medicine in the Internal Medicine Clinic of General Hospital of Syros June 2011- June 2012: Rural service as physician (General Medicine) in Efyra Regional Office- Simopoulo Health Center in Amaliada- Peloponnesus (The first three months I worked as a doctor in General Hospital of Amaliada) February 2011- June 2011: I worked as a physician in Vamvas Medicals Enterprise. Teaching Experience: Please highlight teaching experience (e.g undergraduate or postgraduate) 2014-2015: Professor in Pharmacology-Anatomy- Physiology- First Aid-Hygiene- Paediatrics- Microbiology in Acme College in Piraeus 2013-2014: Senior lecturer at Aegean Omiros College teaching: Molecular Biology and Genetics, (1 semester), BSc (Hons) in Dietetics 2013-2014: Professor in Pharmacology in the Drugstore Assistant Public School in Nea Smyrni-Athens. 2013-2014: Professor in Pharmacology in the Drugstore Assistant Public School in Helioupolis-Athens. 2013-2014: Professor in Anatomy- Physiology- Dermatology in the Heardressing Public School in Iraklion- Athens 2012-2013: Professor in Pharmacology in the Nursing Assistant Public School in Syros. 2011- 2012: Professor in Anatomy- Physiology- Neurology- Pediatrics- Microbiology in Acme College in Patras Published output from research and scholarly activity:
Abstract
T786C polymorphism of eNOS gene and risk of developing atherosclerosis in women with endopelvic endometriosis Georgios Dryllisa, Vasilios Kelarisb, Emmanouil Logothetisc, Marianna Politoud, Emmanouil Economouc, Argyri Gialerakie, Vasilios Tsamadiasc, Nikolaos Machairiotisf and Evangelia Kouskounic a Pathology and Physiology Department, â?oLaikoâ? General Hospital, School of Medicine, University of Athens, Athens, Greece b Specialist Obstrecian and Gynecologist, Athens, Greece c Laboratory of Microbiology, Aretaieio General Hospital, School of Medicine, University of Athens, Athens, Greece d Laboratory of Haematology and Blood Transfusion Unit, Aretaieio General Hospital, School of Medicine, University of Athens, Athens, Greece e Laboratory of Haematology and Blood Transfusion Unit, Aretaieio General Hospital, School of Medicine, University of Athens, Athens, Greece f Obstetric-Gynecology Department, â?oThriassioâ? General Hospital of Athens, Athens, Greece Introduction: Endometriosis affects younger women, while atherosclerosis is a disease that occurs in elder women. These two diseases, with no apparent connection between them, represent situations where activated macrophages and lipoproteins come together. Both have tissue macrophages that expressing specific receptors and these receptors are exposed to lipoproteins. In both diseases, the common features include: chemotaxis, conservation of monocyte/macrophage differentiation, development of monocytes and smooth muscle cells (or endometrial cells), activation of the inflammatory process, and cytotoxicity. Endothelial nitric oxide synthase (eNOS) plays an important role in the regulation of cardiovascular function. There are some studies that relating the impact of T786C polymorphism of eNOS gene in the development of premature myocardial infraction (MI) in individuals whose coronary arteries are characterized by atheromatic burden. In particular, homozygosity for T786C has been shown to lead to elevated eNOS production. Objective: In our study we examined whether patients with endometriosis express the T786C polymorphism of eNOS gene and so if there is a strong correlation between endometriosis and the development of atherosclerosis in the same patients. Methods: We recruited 17 patients with endopelvic endometriosis and we compared them to 103 controls without endometriosis and atherosclerosis. Results: We found that 18% of patients with endopelvic endometriosis have homozygosity for the T786C allele of the eNOS gene (so CC genotype) compared to 6% of the controls. Also, we showed that there is a significant high T786C allele frequency of 44% in patients with endometriosis, while in the control group the frequency is 19%. Conclusions: Our data suggest that there is a significant higher frequency of homozygosity for the T786C allele of the eNOS gene (CC genotype) in patients with endopelvic endometriosis compared to the control group. So it seems that patients with endopelvic endometriosis have a significant risk of developing atherosclerosis sometime in their life .