Thrombosis and Hemostasis

Resident physician in the specialty of Hematology in Laiko General University Hospital of Athens Education and Qualifications (with dates and Institutions details):\r\n\r\n\r\n\r\n\r\n\r\n\r\n \r\nAthens: 2013- nowadays: \r\nPh. D Candidate of the Medical School of Athens on the thesis: Gene polymorphisms and pregnancy outcome\r\n\r\nAlexandroupolis: 2005- 2010: \r\nBachelor studies in Medical School of Democritus University of Thrace and graduation in 2010 with grade: very well- 7,07/10. \r\n\r\nPatras: 2005-2007: \r\nStudies in the post-graduate program â?~Applications in Basic Medical Sciencesâ?T, Medical School in University of Patras. \r\nM. Sc graduation in 2007 with grade: excellent â?\" 10/10.\r\nM. Sc Thesis: Construction of episomal vector for the activation of the artificial transcription factor of g-globin gene in human hematopoietic stem cells. Molecular genetics and Cytogenetics sector, Supervisor Mrs. Aglaia Athanassiadou\r\n2005-2007: I gained scholarship from the â?~State Scholarships Foundationâ?T.\r\n\r\nAlexandroupolis: 2000-2004: \r\nBachelor studies in Molecular Biology and Genetics School of Democritus University of Thrace and graduation in 2004 with grade: very well- 8,21/10.\r\nThesis: Clinical and molecular study of major beta-thalassemia mutations in Greece. I worked for seven months in the laboratory of prenatal diagnosis in hemoglobinopathies in Laiko Hospital, with Mrs. Loutradi-Anagnostou as Supervisor\r\n

Introduction: Endometriosis affects younger women, while atherosclerosis is a disease that occurs in elder women. These two diseases, with no apparent connection between them, represent situations where activated macrophages and lipoproteins come together. Both have tissue macrophages that expressing specific receptors and these receptors are exposed to lipoproteins. In both diseases, the common features include: chemotaxis, conservation of monocyte/macrophage differentiation, development of monocytes and smooth muscle cells (or endometrial cells), activation of the inflammatory process, and cytotoxicity.\r\nEndothelial nitric oxide synthase (eNOS) plays an important role in the regulation of cardiovascular function. There are some studies that relating the impact of T786C polymorphism of eNOS gene in the development of premature myocardial infraction (MI) in individuals whose coronary arteries are characterized by atheromatic burden. In particular, homozygosity for T786C has been shown to lead to elevated eNOS production.\r\nObjective: In our study we examined whether patients with endometriosis express the T786C polymorphism of eNOS gene and so if there is a strong correlation between endometriosis and the development of atherosclerosis in the same patients.\r\nMethods: We recruited 17 patients with endopelvic endometriosis and we compared them to 103 controls without endometriosis and atherosclerosis. Results: We found that 18% of patients with endopelvic endometriosis have homozygosity for the T786C allele of the eNOS gene (so CC genotype) compared to 6% of the controls. Also, we showed that there is a significant high T786C allele frequency of 44% in patients with endometriosis, while in the control group the frequency is 19%. \r\nConclusions: Our data suggest that there is a significant higher frequency of homozygosity for the T786C allele of the eNOS gene (CC genotype) in patients with endopelvic endometriosis compared to the control group. So it seems that patients with endopelvic endometriosis have a significant risk of developing atherosclerosis sometime in their life .\r\n